Learning Objectives and References for Elective Course Students

• Explain histologic classification of endometrial cancer
• Explain molecular classification of endometrial cancer
  • https://www.annalsofoncology.org/article/S0923-7534(22)01207-8/fulltext
• Explain microsatellite instability test
  • CAP guideline
    • https://meridian.allenpress.com/aplm/article/doi/10.5858/arpa.2021-0632-CP/484203/Mismatch-Repair-and-Microsatellite-Instability
  • Microsatellite instability
    • https://www.sciencedirect.com/science/article/pii/S0923753419312694
  • Peptide nucleic acid probe (PNA)-mediated real-time PCR-based method
    • https://bmccancer.biomedcentral.com/articles/10.1186/s12885-018-5127-6
• Explain mismatch repair deficiency test
  • Immunohistochemistry
    • https://www.sciencedirect.com/science/article/pii/S0923753419312694
  • Interpretation
    • https://www.thebagp.org/wp-content/uploads/download-manager-files/1593411202wpdm_BAGP%20MMR%20IHC%20Interpretation%20June%202020.pdf
  • Lynch syndrome
• Explain variant pathogenesis
  • NM_000179.3(MSH6):c.2314C>T (p.Arg772Trp)
  • https://gnomad.broadinstitute.org/
  • https://www.ncbi.nlm.nih.gov/clinvar/
  • https://www.nature.com/articles/gim201530